DSIP 10mg Vial
High purity research peptide – for laboratory use only
$35.00
Out of stock
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide (Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val) first identified in rabbit brain extracts. It’s studied in research settings for its potential to regulate sleep, reduce stress, and modulate various physiological processes. Below are the potential benefits of DSIP based on preclinical studies, animal models, and limited human data, focusing on its mechanisms and applications.Potential Benefits of DSIP
Improved Sleep Quality:
DSIP is best known for promoting deep, restorative sleep, particularly slow-wave (delta) sleep, in animal models. It may regulate circadian rhythms and enhance sleep onset and duration.
Studies in rabbits and rats show DSIP administration increases delta sleep and reduces sleep disturbances, potentially via modulation of brain neurotransmitters like GABA and serotonin.
Stress Reduction and Neuroprotection:
DSIP exhibits stress-protective effects in animal studies, reducing cortisol levels and mitigating the physiological impact of stress. It may stabilize the hypothalamic-pituitary-adrenal (HPA) axis, which regulates stress responses.
Research suggests DSIP protects neurons from oxidative stress and excitotoxicity, potentially benefiting models of neurodegenerative diseases or brain injury.
Pain Modulation:
DSIP has shown analgesic properties in preclinical studies, particularly in models of chronic pain. It may interact with opioid receptors or modulate pain pathways, reducing pain perception in animals.
Limited human studies suggest potential for alleviating chronic pain conditions, though mechanisms are not fully understood.
Hormonal and Metabolic Regulation:
DSIP influences hormone secretion, including growth hormone, ACTH, and melatonin, in animal models. This may support metabolic balance and circadian rhythm alignment.
Studies in rats indicate DSIP normalizes glucose metabolism and insulin sensitivity, suggesting potential in metabolic disorder research.
Anti-Anxiety and Mood Stabilization:
DSIP reduces anxiety-like behaviors in animal models, possibly by modulating GABAergic systems or reducing HPA axis overactivity.
Anecdotal reports and small human studies suggest DSIP may improve mood and emotional stability, though evidence is limited.
Antioxidant and Anti-Aging Effects:
DSIP may reduce oxidative stress by enhancing antioxidant enzyme activity (e.g., superoxide dismutase) in preclinical studies. This could protect cells from age-related damage.
Its stress-reducing and sleep-enhancing effects may indirectly support longevity by mitigating chronic stress and improving cellular repair during sleep.
Immune System Support:
Preliminary research indicates DSIP may modulate immune function, potentially by reducing stress-induced immunosuppression. Animal studies show improved immune markers under stress conditions.
Its role in inflammation control is less clear but may involve cytokine regulation.
Administration and Research Context
Forms: DSIP is typically administered via subcutaneous or intravenous injection in research settings, with doses ranging from 10–100 µg/kg in animal studies. Oral bioavailability is low, and human dosing is not standardized.
Stability: DSIP is sensitive to degradation and requires proper storage (2–8°C, lyophilized form reconstituted with bacteriostatic water).
Research Use: DSIP is sold as a research chemical, not approved for human use by regulatory bodies like the FDA. It’s studied in contexts like sleep disorders, stress, and neurological conditions.