Dihexa 10mg
Cognitive enhancement peptide
$42.00
Out of stock
What is Dihexa?
Dihexa (also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide or PNB-0408) is an experimental synthetic peptide derived from angiotensin IV, part of the renin-angiotensin system. It was developed to enhance cognitive function by promoting synaptogenesis—the formation of new synaptic connections between neurons—and increasing neuroplasticity. Dihexa is designed to cross the blood-brain barrier easily, making it more bioavailable than its parent compounds. It's primarily studied in preclinical models (e.g., rats and mice) for neurodegenerative conditions, but human data remains limited, and it's not FDA-approved for therapeutic use. It's often explored in research or off-label contexts for brain health optimization.
Key Benefits of Dihexa
Based on preclinical studies and early research, Dihexa shows promise in several areas of cognitive and neurological health. These benefits stem from its ability to activate the hepatocyte growth factor (HGF)/c-Met signaling pathway, mimic brain-derived neurotrophic factor (BDNF), and reduce inflammation. Here's a summary of the most commonly reported benefits:
Benefit | Description | Supporting Evidence |
|---|---|---|
Improved Memory Formation and Recall | Enhances encoding, retention, and retrieval of information by boosting synaptic density and neural circuitry. | Rat models of cognitive dysfunction showed restored spatial learning and memory in Morris water maze tests; increased neuronal cells and synaptophysin (SYP) protein expression in Alzheimer's mouse models (APP/PS1). |
Enhanced Learning and Skill Acquisition | Supports faster information processing, focus, and mental clarity, potentially aiding students or professionals. | Preclinical data indicates better performance on spatial working memory and passive avoidance tasks; anecdotal reports note quicker skill uptake. |
Neuroprotection and Brain Repair | Promotes neuronal regeneration, reduces inflammation (e.g., lowers IL-1β and TNF-α, boosts IL-10), and aids recovery from injuries like traumatic brain injury (TBI) or stroke. | Restored nerve function in rat sciatic nerve injury models (nearly complete recovery in 8 weeks); decreased astrocyte/microglia activation in Alzheimer's models via PI3K/AKT pathway. |
Synaptogenesis and Neuroplasticity | Stimulates new synapse formation, mimicking BDNF to strengthen brain networks and potentially reverse age-related decline. | Increased dendritic spines/synapses in rat models; supports long-term neural changes rather than temporary boosts. |
Potential for Neurodegenerative Diseases | May slow or reverse cognitive impairment in conditions like Alzheimer's, Parkinson's, or ADHD by fostering new connections and emotional well-being. | Improved cognition in scopolamine-induced deficits; ongoing trials of analogs (e.g., ATH-1017) for Alzheimer's/Parkinson's. |
These benefits are most evident in models of impaired cognition, with little effect on healthy brains. When combined with therapies like mesenchymal stem cells, outcomes for nerve repair appear amplified.
Mechanism of Action
Dihexa binds to hepatocyte growth factor (HGF) and modulates receptors like AT4R (angiotensin IV receptor), activating pathways such as PI3K/AKT for anti-apoptotic and anti-inflammatory effects. This leads to elevated BDNF levels, promoting neuron survival, growth, and connectivity. Unlike traditional nootropics, it targets structural brain changes for potentially lasting results.