ARA290 (Cibinetide)
99% Purity Weight-Loss Supplement
$39.00
Out of stock
ARA290 is an 11-amino acid synthetic peptide engineered from the helix B domain of erythropoietin. Unlike full EPO, ARA290 selectively activates the innate repair receptor (a heterodimer of the EPO receptor and CD131/β-common receptor), triggering anti-inflammatory cascades, reducing cytokine production, inhibiting apoptosis, and promoting tissue regeneration and nerve repair.
Key features:
Non-erythropoietic: No red blood cell stimulation or associated risks like thrombosis.
Short half-life but potent local effects: Activates protective pathways in injured tissues.
High purity: Typically ≥99% (HPLC verified).
Form: Lyophilized powder for reconstitution.
Common research applications: Neuropathic pain models, small fiber neuropathy, diabetic complications, sarcoidosis-associated nerve damage, inflammatory conditions, and tissue injury/repair studies.
Extensively studied in preclinical models and Phase II clinical trials for conditions like sarcoidosis-related small fiber neuropathy and diabetic neuropathy, where it demonstrated improvements in nerve fiber density, pain reduction, and metabolic parameters.For research use only. Not for human consumption or therapeutic use.Key Benefits (Based on Preclinical & Clinical Research)
Neuropathic Pain Relief — Reduces allodynia and chronic neuropathic symptoms; long-term pain suppression observed in models via microglia modulation and anti-inflammatory effects.
Nerve Regeneration & Repair — Increases corneal nerve fiber density and promotes small nerve fiber regrowth in neuropathy models (e.g., sarcoidosis, diabetes).
Powerful Anti-Inflammatory Action — Downregulates pro-inflammatory cytokines, inhibits NLRP3 inflammasome activation, and shifts immune response toward resolution and healing.
Tissue Protection & Cytoprotection — Prevents cell death (anti-apoptotic), protects against ischemia-reperfusion injury, and supports organ/ tissue recovery in models of diabetes, heart failure, and more.
Metabolic Support — Improves insulin sensitivity and metabolic control in type 2 diabetes models without hematopoietic side effects.
Potential Broader Applications — Explored in depression-like behavior (anti-inflammatory effects on microglia), ocular conditions like diabetic macular edema, and post-transplant islet cell survival.
Additional Information
Molecular Sequence: PyroGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser (cyclized N-terminal pyroglutamate form)
Molecular Weight: ≈1257 Da
Storage: Lyophilized: Store at -20°C or colder. Reconstituted: Use sterile bacteriostatic water; refrigerate and use within the recommended period to maintain stability.
Reconstitution: Typically 1-2 mL bacteriostatic water per vial; gentle swirling (avoid shaking).
Research Dosing Examples (from studies; for lab use only): 1-8 mg/day subcutaneous in human trials; preclinical doses vary widely.
Synonyms: Cibinetide, ARA-290, Helix B surface peptide (HBSP), pHBSP
Disclaimer: This product is intended solely for in vitro research and laboratory experimentation. Any use outside of approved research protocols is prohibited. No claims are made regarding safety or efficacy for human use. Consult relevant literature and institutional guidelines.
This peptide represents a cutting-edge tool for studying the IRR pathway and developing novel approaches to inflammation-driven and neuropathic disorders. Explore the science behind ARA290 in peer-reviewed publications on PubMed and clinical trial registries.