5-Amino-1MQ

5-Amino-1MQ (also written as 5-amino-1MQ or 5-amino-1-methylquinolinium) is a small-molecule compound that acts as an inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). NNMT is involved in regulating cellular metabolism, particularly in fat tissue, where elevated levels contribute to fat storage, reduced energy efficiency, and lower NAD+ (a key molecule for mitochondrial function and cellular energy).By blocking NNMT, 5-Amino-1MQ helps preserve higher NAD+ levels, reduces fat cell expansion, and shifts metabolism toward better fat burning and energy use. This mechanism has drawn interest in wellness, anti-aging, and metabolic health communities.Key Reported BenefitsMost benefits come from preclinical studies (primarily in mice and cell models) and anecdotal/clinical observations from wellness providers. Human clinical trials are limited or ongoing, so these are not fully established or FDA-approved for any medical use.

• Weight Loss and Fat Reduction: It promotes fat metabolism, reduces body weight, white adipose tissue mass, and adipocyte (fat cell) size in diet-induced obese mice. It supports fat burning without significantly affecting appetite (unlike GLP-1 drugs like semaglutide).

• Preservation of Lean Muscle Mass: Helps maintain muscle while targeting fat loss, potentially useful during calorie restriction or training.

• Improved Metabolic Health and Insulin Sensitivity: Enhances glucose handling, reduces insulin resistance, and supports better blood sugar regulation.

• Increased Energy and Endurance: By boosting NAD+ and mitochondrial efficiency, it may reduce fatigue, improve endurance, and support overall cellular energy production.

• Potential Anti-Aging and Longevity Support: Higher NAD+ levels activate pathways like SIRT1 (linked to longevity), reduce inflammation, and improve mitochondrial function. Some combine it with NAD+ therapy for amplified effects on aging markers, such as better tissue repair and reduced senescence.

• Other Potential Benefits: Support for cardiovascular or kidney health (mentioned anecdotally), reduced inflammation, and possibly better recovery from exercise (e.g., improved grip strength and shorter recovery in aged mice models).

A key study (published in Biochemical Pharmacology, 2018) showed that 5-Amino-1MQ reversed high-fat diet-induced obesity in mice by reducing body weight, fat mass, adipocyte size, and plasma cholesterol, while increasing NAD+ and suppressing fat formation in cells.More recent work (e.g., 2024-2025) has explored its role in muscle strength in aged models and synergy with calorie restriction or NAD+ boosters.Note that while promising in animal models, human evidence is mostly from observational reports or small-scale use in peptide/ wellness clinics. It's often taken orally as capsules. Always consult a healthcare professional before use, as it's not a regulated drug, and long-term safety/efficacy in humans isn't fully proven. Side effects appear minimal in reports, but research is early-stage.